| Titre : | The impact of Vitamin D deficiency on Anxiety and Depression in region of Saïda and Sidi Bel Abbes |
| Auteurs : | Nasr-Eddine KEBIR, Directeur de thèse ; Ibtissem Khefif, Auteur |
| Type de document : | texte imprimé |
| Editeur : | saida [algerie] : Université dr Moulay Tahar, 2024 |
| Format : | 104p |
| Accompagnement : | cd |
| Langues: | Français |
| Mots-clés: | vitamin D ; depression ; anxiety ; immune system ; inflammation ; neuroinflammation psychiatry. |
| Résumé : |
Depression and anxiety are psychiatric and mood disorders that affect health and therefore
quality of life and increase the global burden of disease. Vitamin D, a fat-soluble vitamin, is well-known for its role in bone health, is involved in several brain processes, including neuroimmune regulation, neurotrophic factor regulation, neuroprotection, neuroplasticity, and brain development and recently emerged it’s impact on mental health where the brain regions involved in the pathophysiology of depression and anxiety and vitamin D metabolism intersect. Vitamin D deficiency is widespread worldwide impacts brain structure and function and it has been linked to an increased risk of depression and anxiety. One of the possible mechanisms in the pathophysiology of these psychiatric disorders has been reported as oxidative stress and inflammation. In light of this information, our goal is to determine the importance of vitamin D on psychiatric disorders such as depression and anxiety. We conducted two evaluations of vitamin D levels. The initial assessment involved 525 individuals from the general population to gauge their vitamin D status. Among them, 412 individuals, constituting 78% of the total, had insufficient vitamin D levels ( 86% being women and 14% men. Acceptable vitamin D levels (30 to 50 ng/mL) were observed in 83 individuals, comprising 15% of the total population, with 87% being women and 13% men. Approximately twenty individuals, accounting for 3% of the total, had optimal vitamin D levels (50-70 ng/mL), with 95% being women and 5% men. Therapeutic levels (≥70 ng/mL) were found in 8 individuals, representing 1.5% of the total, with 62% being women and 37% men. The prevalence of vitamin D levels exceeding 100 ng/mL was extremely low, with only 2 individuals, or 0.3% of the total, and they were exclusively female. The second evaluation on a population of 100 subjects with psychiatric disorders which included three groups of different ages and sexes: 1 to 15 years, 15 to 50 years, and 50 years and above. Among those aged 1 to 15 years, 1% were girls, and in the 15 to 50 years group, 52% were women and 29% men, while in the 50 years and above group, 14% were women and 3% men. Within these groups, individuals suffered from various mental disorders such as schizophrenia, Alzheimer's, bipolar disorder, anxiety, depression, OCD (obsessive-compulsive disorder), GAD (generalized anxiety disorder), and social phobia. Among them, 80 individuals had vitamin D deficiency. The prevalence of vitamin D insufficiency ( with mental disorders primarily affected women, with 66% of women and 33% of men suffering from anxiety and depression experiencing this deficiency. Of the 100 subjects evaluated, almost the majority (80%) suffered from vitamin D deficiency. Clearly spending time in the sunshine and/ or exercising outdoors, eating food that is rich of vitamin D, taking dietary supplements to improve vitamin D deficiency may improve mental well-being in patients with depression. Vitamin D screening should be performed in the prevention and treatment planning of these mood disorders. |
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Documents numériques (1)
SNVTM001019 Adobe Acrobat PDF |
